influential variables too (Singh et al. 2011a, c; Raza et al. 2013). Major CQAs, in this

context, included nanometric size, zeta potential, drug release profile, stability, drug

entrapment efficiency and also organoleptic attributes (Singh et al. 2011a, c; Li et al.

2017; Singh et al. 2005b). The predictive capability of FbD optimization methods is

often ratified by characterizing and evaluating a variety of checkpoint nanostructured

4000

5000

4000

3500

3000

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2500

2000

2000

1500

1000

1000

500

0

0

<1980

1981-90

1991-2000

2001-10

2011-20

<1980

1981-90

1991-2000

2001-10

2011-20

Years

Cumulative number of

publications

Other novel drug systems

nanostructured drug delivery systems

Fig. 18.11 A sequential bar chart of the mounting usage of QbD during systematic development of

various drug nanoconstructs

Fig. 18.12 A pie diagram depicting application of QbD on variegated kinds of drug

nanoconstructs

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B. Singh et al.